Bullous Pemphigoid Information and Treatment
Bullous pemphigoid is a blistering skin disease
which usually affects middle aged or elderly persons. It is an
immunobullous disease, i.e. the blisters are due an immune reaction
within the skin. Bullous pemphigoid is diagnosed based on the
results of a skin biopsy, which can detect the abnormal antibodies
deposited in the basement membrane layer of skin. Bullous pemphigoid-like
condition can sometimes be associated with other illnesses,
including systemic lupus erythematosus (SLE or lupus) and cancer.
The cause of bullous pemphigoid is unknown, but it may be related to
a disorder of the immune system. Bullous pemphigoid typically occurs
in older adults. The condition is seldom life- threatening, but the
medications used to treat bullous pemphigoid can cause
complications. Without treatment, bullous pemphigoid may persist,
with periods of remission and flare-ups, for many years.
Bullous pemphigoid , also referred to as BP , is
a chronic autoimmune skin disease , involving the formation of
blisters below the surface of the skin and antibodies against
collagen. The antigen of this autoimmune disease is localized to the
hemidesmosome . Most cases of the disease are in older people but
the disease can affect younger people, even babies. Bullous
pemphigoid can be chronic, mild and not affect the general health or
it can be severe and compromise the health of the sufferer.
Diagnosis is by skin biopsy. Corticosteroids are used initially.
Most patients require long-term maintenance therapy, for which a
variety of drugs can be used. In bullous pemphig