Darier's Disease Information and Treatment
Darier's disease is a genetic disorder discovered
by a French dermatologist Ferdinand-Jean Darier. It results in dark
crusty patches on the skin which at times contain pus. The crusty
patches are also known as keratotic papules and also called
keratosis follicularisis. It is hereditary disease and is dominant.
It tends to affect both genders but is not condidered to be
contagious. With the discovery of the ATP2A2 gene, performing
genetic tests to confirm the diagnosis of DD is now possible. This
disease is also referred to as keratosis follicularis. It is
considered to be a rare genetic disorder which is predominantly
manifested by skin changes. Usually in adolescence the onset of skin
changes occur and the disease is generally chronic. It gets
inherited by an autosomal dominat pattern which implies that a
single gene that passes on from one parent causes this condition.
Not every human being with abnormal gene develops symptoms of this
disease. It can be diagnosed by its appearance and family history
but is sometimes mistaken for other skin problems. For diagnosing
Darier's disease a skin biopsy may be required. It most commonly
affects the chest, neck, back, ears, forehead, and groin, but may
involve other body areas. At times the rash will cause a bad odor.
This disease can also cause the fingernails to be fragile at the
tips causing V-shaped notches at the end of the nails as pictured
Darier's Disease is a chronis skin disorder.
Darier's Disease is a common condition which can occur in any age
group. Darier disease is a stubborn rash which usually runs in
families. Darier's disease is an autosomal dominantly inherited skin
disorder, characterized by loss of adhesion between epidermal cells
and abnormal keratinization. Darier's Disease is an autosmoal
dominant disease that typically arises during the first or second
decades of life. It involves the abnormal keratinization of the
epidermis, mucosa, and nails.